2. Apoptosis
  3. Apoptosis
  4. IV-23

IV-23 (Compound 20) 是一种有效的 Noxa 介导的细胞凋亡诱导剂，它是一种有潜力的有前景的抗癌剂。IV-23 在体外和体内抑制细胞生长，减少集落形成，在 M 期停滞细胞周期，并抑制食管鳞状细胞癌 (ESCC)。

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IV-23 Chemical Structure

IV-23 Chemical Structure

CAS No. : 2326007-49-0

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IV-23 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IV-23 (Compound 20) is a potent Noxa mediated apoptosis inducer, and it is a promising anticancer agent with potential. IV-23 inhibits cell growths in vitro and in vivo, reduces colony formation, arrests cell cycle at M phase, and induces esophageal squamous cell carcinoma (ESCC)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
6.82 μM
Compound: 9d
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay
[PMID: 34022412]
A549 IC50
6.82 μM
Compound: 9d
Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay
[PMID: 33965530]
ECa-109 cell line IC50
2.24 μM
Compound: 9d
Antiproliferative activity against human Eca-109 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay
Antiproliferative activity against human Eca-109 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay
[PMID: 34022412]
ECa-109 cell line IC50
2.24 μM
Compound: 9d
Antiproliferative activity against human Eca-109 cells incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human Eca-109 cells incubated for 48 hrs by CCK8 assay
[PMID: 33965530]
KYSE-30 IC50
1.61 μM
Compound: 9d
Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay
Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay
[PMID: 34022412]
KYSE-30 IC50
1.61 μM
Compound: 9d
Antiproliferative activity against human KYSE-30 cells incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human KYSE-30 cells incubated for 48 hrs by CCK8 assay
[PMID: 33965530]
KYSE-450 IC50
1.49 μM
Compound: 9d
Antiproliferative activity against human KYSE-450 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay
Antiproliferative activity against human KYSE-450 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay
[PMID: 34022412]
KYSE-450 IC50
1.49 μM
Compound: 9d
Antiproliferative activity against human KYSE-450 cells incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human KYSE-450 cells incubated for 48 hrs by CCK8 assay
[PMID: 33965530]
KYSE-510 IC50
2.08 μM
Compound: 9d
Antiproliferative activity against human KYSE-510 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay
Antiproliferative activity against human KYSE-510 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay
[PMID: 34022412]
KYSE-510 IC50
2.08 μM
Compound: 9d
Antiproliferative activity against human KYSE-510 cells incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human KYSE-510 cells incubated for 48 hrs by CCK8 assay
[PMID: 33965530]
MGC-803 IC50
1.84 μM
Compound: 9d
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay
[PMID: 34022412]
MGC-803 IC50
1.84 μM
Compound: 9d
Antiproliferative activity against human MGC-803 cells incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human MGC-803 cells incubated for 48 hrs by CCK8 assay
[PMID: 33965530]
体外研究
(In Vitro)

IV-23 (Compound 20) shows a strong inhibition against the ESCCs in a concentration depend manner, the IC50 values against the Kyse30 and Kyse450 cell lines were all less than 2 μM, presented in a dose-dependent manner. IV-23 triggeres caspases related apoptosis in ESCC cells[1].
IV-23 induces G2/M phase arrest[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IV-23 相关抗体:
分子量

392.24

Formula

C18H18BrNO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IV-23 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IV-232326007-49-0IV23IV 23ApoptosisInhibitorinhibitorinhibit

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