2. Apoptosis
  3. Apoptosis
  4. IVHD-valtrate

IVHD-valtrate 是一种活性Valeriana jatamansi ?的衍生物，在体内外对人卵巢癌细胞均有抑制作用。IVHD-valtrate 诱导癌细胞凋亡 (apoptosis)，抑制卵巢癌细胞停滞在 G2/M 期。IVHD-valtrate 有潜力成为用于人类卵巢癌研究的一种新的化疗试剂。

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IVHD-valtrate Chemical Structure

IVHD-valtrate Chemical Structure

CAS No. : 28325-56-6

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IVHD-valtrate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IVHD-valtrate, an active Valeriana jatamansi derivative, is against human ovarian cancer cells in vitro and in vivo. IVHD-valtrate induces cancer cells apoptosis and arrests the ovarian cancer cells in the G2/M phase. IVHD-valtrate has the potential to be a novel chemotherapeutic agent for the human ovarian cancer research[1].

IC50 & Target

IC50: apoptosis[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
7.4 μM
Compound: 18
Cytotoxicity against human A549 cells after 24 hrs by MTT assay
Cytotoxicity against human A549 cells after 24 hrs by MTT assay
[PMID: 19245261]
Bel-7402 IC50
4 μM
Compound: 18
Cytotoxicity against human Bel7402 cells after 24 hrs by MTT assay
Cytotoxicity against human Bel7402 cells after 24 hrs by MTT assay
[PMID: 19245261]
HCT-8 IC50
2.5 μM
Compound: 18
Cytotoxicity against human HCT8 cells after 24 hrs by MTT assay
Cytotoxicity against human HCT8 cells after 24 hrs by MTT assay
[PMID: 19245261]
PC-3M IC50
1.9 μM
Compound: 18
Cytotoxicity against human PC3M cells after 24 hrs by MTT assay
Cytotoxicity against human PC3M cells after 24 hrs by MTT assay
[PMID: 19245261]
体外研究
(In Vitro)

IVHD-valtrate inhibits the growth and proliferation of the A2780 and OVCAR-3 ovarian cancer cell lines in a concentration-dependent manner[1].
IVHD-valtrate results in a relatively low cytotoxicity to immortalized non-tumorigenic human ovarian surface epithelial cells (IOSE-144)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IVHD-valtrate 相关抗体:
分子量

540.60

Formula

C27H40O11
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IVHD-valtrate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IVHD-valtrate28325-56-6Apoptosischemotherapeutichuman ovariancancertumorapoptosis A2780OVCAR-3epithelial cellInhibitorinhibitorinhibit

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