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JCC76 是 Nimesulide (HY-B0363) 的衍生物。JCC76 抑制 Her2 阳性乳腺癌细胞 SKBR-3 增殖，IC50 为 3.43 μM。

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JCC76 Chemical Structure

JCC76 Chemical Structure

CAS No. : 1021926-22-6

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JCC76 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JCC76 is the derivative of Nimesulide (HY-B0363). JCC76 inhibits the proliferation of Her2 positive breast cancer cell SKBR-3 with IC50 of 3.43 μM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
NCI-H292 IC50
22.1 μM
Compound: 40
Antiproliferative activity against human NCI-H292 cells in 3D multi-cellular spheroid form after 7 days by inverted microscopy
Antiproliferative activity against human NCI-H292 cells in 3D multi-cellular spheroid form after 7 days by inverted microscopy
[PMID: 23306053]
NCI-H292 IC50
7.99 μM
Compound: 40
Antiproliferative activity against human NCI-H292 2D monolayer cells after 3 days by MTT assay
Antiproliferative activity against human NCI-H292 2D monolayer cells after 3 days by MTT assay
[PMID: 23306053]
SK-BR-3 IC50
1.38 μM
Compound: 3, JCC76
Growth inhibition of human SKBR3 cells after 48 hrs by MTT assay
Growth inhibition of human SKBR3 cells after 48 hrs by MTT assay
[PMID: 22435708]
SK-BR-3 IC50
1.38 μM
Compound: JCC76
Cytotoxicity against human SK-BR-3 cells after 48 hrs by MTT assay
Cytotoxicity against human SK-BR-3 cells after 48 hrs by MTT assay
[PMID: 22119125]
SK-BR-3 IC50
3.17 μM
Compound: 49, JCC76
Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT assay
Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT assay
[PMID: 23767669]
SK-BR-3 IC50
3.43 μM
Compound: JCC76
Antiproliferative activity against human SKBR3 cells after 48 to 72 hrs by MTT assay
Antiproliferative activity against human SKBR3 cells after 48 to 72 hrs by MTT assay
[PMID: 21807508]
分子量

444.59

Formula

C24H32N2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JCC76 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JCC761021926-22-6JCC 76JCC-76OthersSKBR-3Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-124454
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