2. Neuronal Signaling
  3. Amyloid-β
  4. JLK-6

JLK-6 通过影响表达HEK293细胞的淀粉样β前体蛋白(APP)的γ-分泌酶裂解APP，显著减少了 Aβ的产生，而不影响Notch受体的裂解。

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JLK-6 Chemical Structure

JLK-6 Chemical Structure

CAS No. : 62252-26-0

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规格 价格 是否有货 数量
10 mg ￥2547
3 - 4 周
50 mg   询价  
100 mg   询价  

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JLK-6 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JLK-6 markedly reduce the production of amyloid β-peptide (Aβ) by amyloid-β Precursor protein (APP) expressing HEK293 cells by affecting the γ-secretase cleavage of APP, with no effect on the cleavage of the Notch receptor[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
30 μM
Compound: 24; JLK6
Inhibition of gamma secretase mediated amyloid beta level reduction in HEK293 cells expressing APP after 72 hrs by chemiluminescence assay
Inhibition of gamma secretase mediated amyloid beta level reduction in HEK293 cells expressing APP after 72 hrs by chemiluminescence assay
[PMID: 27045975]
分子量

225.63

Formula

C10H8ClNO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JLK-6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JLK-662252-26-0JLK6JLK 6Amyloid-ββ-amyloid peptideAβAbetaamyloid βAPPInhibitorinhibitorinhibit

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目录号：
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