2. Apoptosis
  3. Thymidylate Synthase
  4. JMF4073

JMF4073 是一种胸苷酸 (TMP) 和胞苷酸 (CMP) 激酶抑制剂，IC50 分别为 0.16 μM 和 0.17 μM。JMF4073 在体外和体内消除野生型 (WT)-Bcr-Abl 转化的髓系细胞。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

JMF4073 Chemical Structure

JMF4073 Chemical Structure

CAS No. : 1927930-61-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

JMF4073 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JMF4073 is a thymidylate (TMP) and cytidylate (CMP) kinases inhibitor with IC50s of 0.16 μM and 0.17 μM, respectively. JMF4073 eliminates wild-type (WT)-Bcr-Abl-transformed myeloid cells in vitro and in vivo[1].

体外研究
(In Vitro)

WT-Bcr-Abl 细胞对 JMF4073 高度敏感，GI50 为 0.67 μM，而 T315I-Bcr-Abl-32D 和未转化的 32D 细胞分别为 1.5 μM 和 4.2 μM。这些细胞中的整体酪氨酸磷酸化水平不受 JMF4073 治疗的影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JMF4073 相关抗体:
体内研究
(In Vivo)

JMF4073（5 mg/kg；腹腔注射；每日；持续 14 天）抑制 WT-Bcr-Abl-32D 携带小鼠的白细胞计数。此外，JMF4073 可延长白血病小鼠的生存期[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C3H/HeNCrNarl mice injected with WT-Bcr-Abl-32D chronic myeloid leukemia (CML) cells[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; daily; for 14 days
Result: Prolonged the survival of leukemia mice.
分子量

395.45

Formula

C18H22FN3O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JMF4073 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JMF40731927930-61-7JMF 4073JMF-4073Thymidylate Synthasecytidylate kinasesmyeloid leukemia,Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
JMF4073
目录号：
HY-162698
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z