2. MAPK/ERK Pathway
  3. JNK
  4. JNK2-IN-1

JNK2-IN-1 (Compound J27) 是一种 JNK2 抑制剂 (Kds: 79.2 Μm)。JNK2-IN-1 具有抗炎活性。JNK2-IN-1通过抑制 NF-κB/MAPK 通路的激活来减少 TNF-α 和 IL-6 的释放。JNK2-IN-1 缓解 LPS 诱导的急性肺损伤 (ALI) 和脓毒症症状。

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JNK2-IN-1 Chemical Structure

JNK2-IN-1 Chemical Structure

CAS No. : 2998941-15-2

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JNK2-IN-1 相关抗体

Top Publications Citing Use of Products

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JNK1 JNK2 JNK3 JNK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNK2-IN-1 (Compound J27) is a JNK2 inhibitor (Kds: 79.2 μM). JNK2-IN-1 has anti-inflammatory activity. JNK2-IN-1 decreases the release of TNF-α and IL-6 through inhibiting the activation of NF-κB/MAPK pathway. JNK2-IN-1 alleviates the symptoms of LPS-induced acute lung injury (ALI) and sepsis[1].

IC50 & Target

Kd: 79.2 μM[1]
分子量

522.55

Formula

C30H26N4O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNK2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK2-IN-12998941-15-2JNKc-Jun N-terminal kinaseJ774A.1THP-1ALIsepsisanti-inflammatoryInhibitorinhibitorinhibit

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