2. MAPK/ERK Pathway Protein Tyrosine Kinase/RTK
  3. JNK Discoidin Domain Receptor
  4. JNK3 inhibitor-2

JNK3 inhibitor-2 是一种有效的选择性 JNK3 抑制剂，对于 JNK1、JNK2、 JNK3的 IC50 值分别为 >100, >100, 0.25 µM。JNK3 inhibitor-2 显示出对 DDR1 和 EGFR (T790M, L858R) 的抑制作用。

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JNK3 inhibitor-2 Chemical Structure

JNK3 inhibitor-2 Chemical Structure

CAS No. : 2366264-18-6

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JNK3 inhibitor-2 相关抗体

Top Publications Citing Use of Products

查看 JNK 亚型特异性产品:

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JNK1 JNK2 JNK3 JNK

查看 Discoidin Domain Receptor 亚型特异性产品:

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DDR1 DDR2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNK3 inhibitor-2 is a potent and selective JNK3 inhibitor with IC50 values of >100, >100, 0.25 µM for JNK1, JNK2, JNK3, respectively. JNK3 inhibitor-2 shows DDR1 and EGFR (T790M, L858R) inhibition[1].

IC50 & Target[1]

JNK1

>100 μM (IC50)

JNK2

>100 μM (IC50)

JNK3

0.25 μM (IC50)

体外研究
(In Vitro)

JNK3 inhibitor-2 (compound J46) shows 30% and 60% inhibition to JNK2α2 at 30 μM and 100 μM, respectively[1].
JNK3 inhibitor-2 shows inhibitory ability for DDR1 and EGFR (T790M, L858R) with IC50s of 0.16, 0.37 µM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JNK3 inhibitor-2 相关抗体:
分子量

314.34

Formula

C20H14N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNK3 inhibitor-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK3 inhibitor-22366264-18-6JNKDiscoidin Domain Receptorc-Jun N-terminal kinasequinoxaline derivativeDDR1EGFRInhibitorinhibitorinhibit

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