2. MAPK/ERK Pathway
  3. JNK
  4. JNK3 inhibitor-3

JNK3 inhibitor-3 (compound 15g) 是选择性的、可穿透血脑屏障、口服有效的的 c-Jun N-terminal kinase 3 (JNK3) 抑制剂。JNK3 inhibitor-3 抑制 JNK1，JNK2 和 JNK3 的 IC50 值分别为 147.8，44.0 和 4.1 nM。JNK3 inhibitor-3 显著改善小鼠痴呆模型的记忆功能。JNK3 inhibitor-3 可用于阿尔茨海默病的研究。

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JNK3 inhibitor-3 Chemical Structure

JNK3 inhibitor-3 Chemical Structure

CAS No. : 2873465-25-7

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JNK3 inhibitor-3 相关抗体

Top Publications Citing Use of Products

查看 JNK 亚型特异性产品:

查看所有亚型
JNK1 JNK2 JNK3 JNK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNK3 inhibitor-3 (compound 15g) is a selective, BBB permeable and orally active c-Jun N-terminal kinase 3 (JNK3) inhibitor. JNK3 inhibitor-3 has inhibitory activities to JNK1, JNK2 and JNK3 with IC50 values of 147.8, 44.0 and 4.1 nM, respectively. JNK3 inhibitor-3 significantly improves the memory in mouse dementia model. JNK3 inhibitor-3 can be used for the research of Alzheimer’s disease[1].

IC50 & Target

JNK3

4.1 nM (IC50)

JNK2

44 nM (IC50)

JNK1

147.8 nM (IC50)

体外研究
(In Vitro)

JNK3 inhibitor-3 (0-10 μM) shows inhibitory activities to JNK1, JNK2 and JNK3 with IC50 values of 147.8, 44.0 and 4.1 nM, respectively[1]. JNK3 inhibitor-3 (20 μM; 24 and 48 h) demonstrates neuroprotective effects in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JNK3 inhibitor-3 相关抗体:

Cell Viability Assay[1]

Cell Line: Rat cortical neurons
Concentration: 20 μM
Incubation Time: 24 and 48 hours
Result: Protected rat cortical neurons against 10 μM Aβ1-42 induced neurotoxicity.
体内研究
(In Vivo)

JNK3 inhibitor-3 (30 and 60 mg/kg; oral administration, once daily for 2 or 2.2 month) improves the memory of 3xTg mouse dementia model[1].
1.19 Pharmacokinetic Properties of JNK3 inhibitor-3 in Rats[1].

Rats
IV 1 mg/kg		 Rats
PO 3 mg/kg
AUC (hr•ng/mL) 1085.24 2806.77
Cmax (ng/mL) 1238.85
Tmax (hr) 0.67
T1/2 (hr) 0.36 1.14
BA (%) 86.21

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Homozygous 3xTg and APPswe/PS1dE9 double-transgenic mice model of Alzheimer’s disease[1]
Dosage: 30 and 60 mg/kg
Administration: Oral administration; once daily for 2 or 2.2 month
Result: Induced no abnormal symptoms or weight changes, significantly enhanced the spontaneous alteration in APP/PS1 and doses of 30 and 60 mg/kg than that of vehicle group in Y-maze test and showed a significant difference compared to the 3xTg vehicle control in the passive avoidance test.
分子量

467.52

Formula

C26H25N7O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNK3 inhibitor-3 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK3 inhibitor-32873465-25-7JNKc-Jun N-terminal kinaseselectiveBBB permeablemouse dementia modelAlzheimer’s diseaseneuroprotectiveneuronsInhibitorinhibitorinhibit

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