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  4. JYQ-164

JYQ-164 是一种针对人类的帕金森病蛋白 7 (PARK7/DJ-1) 小分子抑制剂。JYQ-164 通过共价和选择性地靶向 PARK7 的关键残基 Cys106 来发挥作用 (IC50=21 nM)。JYQ-164 对 PARK7 的高抑制效力比之前报道的抑制剂 JYQ-88 相比效力提高了 5 倍。JYQ-164 可用于帕金森病和癌症的研究。

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JYQ-164 Chemical Structure

JYQ-164 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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JYQ-164 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JYQ-164 is a small molecule inhibitor of Parkinson's disease protein 7 (PARK7/DJ-1) in humans. JYQ-164 works by covalently and selectively targeting Cys106, a key residue of PARK7 (IC50=21 nM). The high inhibitory effect of JYQ-164 on PARK7 is 5 times more potent than the previously reported inhibitor JYQ-88. JYQ-164 can be used in Parkinson's disease and cancer research[1].

IC50 & Target

PARK7

21 nM (IC50)

分子量

530.62

Formula

C23H26N6O5S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JYQ-164 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JYQ-164JYQ164JYQ 164OthersCovalent bindingTargeted selectionPara-cancerNeurodegenerative diseasesInhibitorinhibitorinhibit

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