2. GPCR/G Protein
  3. GnRH Receptor
  4. Kisspeptin 13

Kisspeptin-13 抑制葡萄糖诱导的胰岛素分泌，IC50 为 1.2 nM。Kisspeptin 13 激活下丘脑-垂体-肾上腺 (HPA) 轴，引发大鼠体温过高、运动行为和焦虑。Kisspeptin 13 与 α2-肾上腺素能受体和 5-HT2 血清素受体相互作用，表现出抗抑郁功效。Kisspeptin 13 是 GPR54 和 GnRH 受体的激活剂，可增强记忆力，可用于阿尔茨海默病的研究。

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Custom Peptide Synthesis

Kisspeptin 13 Chemical Structure

Kisspeptin 13 Chemical Structure

CAS No. : 374675-18-0

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Kisspeptin 13 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research[1][2][3][4].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
22.8 nM
Compound: 13-mer, metastin-13
Activity at metastin receptor expressed in HEK293 cells by measuring calcium release
Activity at metastin receptor expressed in HEK293 cells by measuring calcium release
[PMID: 17266198]
HEK293 EC50
33 nM
Compound: Y4A
Activity at metastin receptor expressed in HEK293 cells by measuring calcium release
Activity at metastin receptor expressed in HEK293 cells by measuring calcium release
[PMID: 17266198]
体内研究
(In Vivo)

Kisspeptin 13 (intracerebroventricular administration; 2 μg/side; once) treatment improves object recognition memory impairment induced by Aβ through activation of GPR54 and GnRH receptor[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss mice with memory impairment induced by A-beta[1]
Dosage: 2 μg/side
Administration: Intracerebroventricular administration; 2 μg/side; once
Result: Facilitated memory formation and prolonged memory retention through activation of the GPR54 and GnRH receptors, and suppressed memory-impairing effect of Aβ through activation of the GPR54.
分子量

1626.81

Formula

C78H107N21O18
CAS 号
Sequence

Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Sequence Shortening

LPNYNWNSFGLRF-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Kisspeptin 13 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kisspeptin 13374675-18-0Kisspeptin13Kisspeptin-13GnRH ReceptorGonadotropin releasing hormone receptorGNRHRSprague-Dawley ratpertussis toxinhyperthermiaanxietyantidepressantAlzheimer's diseaseswiss mouseInhibitorinhibitorinhibit

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