2. Protein Tyrosine Kinase/RTK
  3. Src
  4. KL-1156

BMS-358233 (compound 3) 是一种 Lck 抑制剂 (IC50: 1 nM；Ki: 540 pM)，可抑制 T 细胞的增殖 (IC50: 262 nM)。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

KL-1156 Chemical Structure

KL-1156 Chemical Structure

CAS No. : 819868-62-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

KL-1156 相关抗体

Top Publications Citing Use of Products

查看 Src 亚型特异性产品:

查看所有亚型
Lck Fyn Blk

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BMS-358233 (compound 3) is a Lck inhibitor (IC50: 1 nM; Ki: 540 pM) and inhibits T cell proliferation (IC50: 262 nM).

IC50 & Target

IC50: 1 nM (Lck)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
NCI-H23 GI50
9.316 μM
Compound: KL-1156
Cytotoxicity against human NCI-H23 cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human NCI-H23 cells assessed as growth inhibition after 72 hrs by SRB assay
[PMID: 24792464]
RAW264.7 IC50
37.2 μM
Compound: KL-1156
Inhibition of NF-kappaB (unknown origin) transcriptional activity in LPS-induced mouse RAW264.7 cells after 1 hr by secreted alkaline phosphatase assay
Inhibition of NF-kappaB (unknown origin) transcriptional activity in LPS-induced mouse RAW264.7 cells after 1 hr by secreted alkaline phosphatase assay
[PMID: 25953156]
RAW264.7 IC50
40.1 μM
Compound: KL-1156
Inhibition of transcriptional activity of NF-kappaB (unknown origin) transfected in LPS-stimulated mouse RAW264.7 cells after 16 hrs by secretory alkaline phosphatase reporter gene assay
Inhibition of transcriptional activity of NF-kappaB (unknown origin) transfected in LPS-stimulated mouse RAW264.7 cells after 16 hrs by secretory alkaline phosphatase reporter gene assay
[PMID: 24792464]
RAW264.7 IC50
53 μM
Compound: KL-1156
Inhibition of LPS-induced NFkappaB (unknown origin) transcriptional activity expressed in mouse RAW264.7 cells incubated for 16 hrs by SEAP based reporter gene assay
Inhibition of LPS-induced NFkappaB (unknown origin) transcriptional activity expressed in mouse RAW264.7 cells incubated for 16 hrs by SEAP based reporter gene assay
[PMID: 27096046]
分子量

299.32

Formula

C17H17NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KL-1156 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KL-1156819868-62-7KL1156KL 1156SrcInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
KL-1156
目录号：
HY-121849
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z