2. Apoptosis
  3. Apoptosis
  4. Kusunokinin

Kusunokinin  (Synonyms: (-)-Kusunokinin)

目录号: HY-N10798
产品使用指南

摩尔计算器

Kusunokinin ((-)-Kusunokinin) 是一种天然产物，可以从 P. nigrum 中分离出来。Kusunokinin 具有抗癌活性。Kusunokinin 可将细胞周期阻滞在 G2/M 期并诱导细胞凋亡 (apoptosis)。

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Kusunokinin Chemical Structure

Kusunokinin Chemical Structure

CAS No. : 58311-20-9

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Kusunokinin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Kusunokinin ((-)-Kusunokinin) is a nature product that could be isolated form P. nigrum. Kusunokinin has anticancer activity. Kusunokinin arrests cell cycle at G2/M phase and induce apoptosis[1].

体外研究
(In Vitro)

Kusunokinin ((-)-Kusunokinin; 0.625-10 µg/mL; 72 h) 抑制癌细胞的活力，对 MCF-7、HT-29、MDA-MB-468、SW-620、A-549 和 MDA-MB-231 细胞的 IC50 值分别为 3.08、3.59、3.98、5.75、5.77 和 7.86 µM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Kusunokinin 相关抗体:

Cell Viability Assay[1]

Cell Line: Cancer cells
Concentration: 0.625, 1.25, 2.5, 5 and 10 µg/mL
Incubation Time: 72 hours
Result: Had anticancer activity and inhibited cancer cells growth.
体内研究
(In Vivo)

Kusunokinin ((-)-Kusunokinin; 7 和 14 mg/kg; i.h.; 每周 3 次, 持续 2 周) 通过下调信号分子 (c-Src、PI3K、Akt 和 Erk1/2) 抑制 NMU 诱导的乳腺癌大鼠的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague Dawley rats (7 weeks of age)[1]
Dosage: 7 and 14 mg/kg
Administration: Subcutaneous injection, 3 times a week for 2 weeks
Result: Inhibited the mammary tumor growth and decreased tumor volume.
Down-regulated c-Src, Erk1/2 and PI3K proteins and decreased Akt proteins.
Inhibited downstream molecules in the cell cycle (c-Myc, E2f-1, CDK1 and cyclin B1) and metastasis (E-cadherin, MMP-2 and MMP-9).
分子量

370.40

Formula

C21H22O6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Kusunokinin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kusunokinin58311-20-9(-)-KusunokininApoptosisnature productP. nigrumanticancercell cycleG2/Mcancer cellsInhibitorinhibitorinhibit

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