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  4. Kv1.5-IN-1

Kv1.5-IN-1是一种Kv1.5通道抑制剂。它在离体大鼠模型中被评估了靶点选择性和药效学作用。Kv1.5-IN-1在R5位置引入甲氧基后，其抑制效力与未取代的化合物相似。它对hKv1.5通道的IC50值为0.51μM。Kv1.5-IN-1展现了高度的选择性，比化合物Ik高出近2600倍，比化合物IId高出300倍，表明它可能是一种安全的抑制剂。由于其良好的药理学行为，Kv1.5-IN-1值得进行进一步的药效学和药代动力学评估。这些特性使Kv1.5-IN-1成为一种有潜力的Kv1.5通道抑制剂，可能在相关疾病的抑制中具有应用前景。

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Kv1.5-IN-1 Chemical Structure

Kv1.5-IN-1 Chemical Structure

CAS No. : 1469902-72-4

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Kv1.5-IN-1 相关抗体

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  • 纯度 & 产品资料

  • 参考文献

生物活性

Kv1.5-IN-1 is a Kv1.5 channel inhibitor. Its target selectivity and pharmacodynamic effects were evaluated in an in vitro rat model. After the introduction of a methoxy group at the R5 position, Kv1.5-IN-1 showed inhibitory potency similar to that of the unsubstituted compound. Its IC50 value for hKv1.5 channels was 0.51 μM. Kv1.5-IN-1 exhibited a high degree of selectivity, nearly 2,600 times higher than compound Ik and 300 times higher than compound IId, indicating that it may be a safe inhibitor. Due to its good pharmacological behavior, Kv1.5-IN-1 deserves further pharmacodynamic and pharmacokinetic evaluation. These properties make Kv1.5-IN-1 a potential Kv1.5 channel inhibitor that may have application prospects in the treatment of related diseases.

分子量

510.99

Formula

C25H23ClN4O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Kv1.5-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

Kv1.5-IN-11469902-72-4OthersInhibitorinhibitorinhibit

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