2. Anti-infection Metabolic Enzyme/Protease
  3. HIV Protease
  4. Kynostatin 272

Kynostatin 272  (Synonyms: KNI 272; Kynostatin; NSC 651714)

目录号: HY-106920
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Kynostatin 272 (KNI 272) 是一种高效的 HIV 蛋白酶抑制剂。Kynostatin 272 通过模拟 HIV 蛋白酶作用的底物过渡态来抑制 HIV 蛋白酶的活性，从而阻止 HIV 病毒复制的关键步骤。Kynostatin 272 为开发 HIV/AIDS 的药物提供了重要的研究基础。

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Kynostatin 272 Chemical Structure

Kynostatin 272 Chemical Structure

CAS No. : 147318-81-8

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Kynostatin 272 相关抗体

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  • 生物活性

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生物活性

Kynostatin 272 (KNI 272) is a potent HIV protease inhibitor. Kynostatin 272 inhibits the activity of the HIV protease by simulating the substrate transition state of the HIV protease, thus preventing a key step in the replication of the HIV virus. Kynostatin 272 provides an important research foundation for the development of drugs for HIV and AIDS[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
H9 EC50
0.02 μM
Compound: KNI-272
Antiviral activity against HIV1 RF in human H9 cells assessed as inhibition of virus-induced cytopathic effect by formazan-based conventional colorimetric technique
Antiviral activity against HIV1 RF in human H9 cells assessed as inhibition of virus-induced cytopathic effect by formazan-based conventional colorimetric technique
[PMID: 11430019]
MT4 CC50
> 30000 nM
Compound: 1
Cytotoxicity against human MT4 cells by MTT assay
Cytotoxicity against human MT4 cells by MTT assay
[PMID: 18426195]
MT4 EC50
22 nM
Compound: 1
Antiviral activity against HIV1 3B in human MT4 cells assessed as inhibition of viral-induced cytopathic effect by MTT method
Antiviral activity against HIV1 3B in human MT4 cells assessed as inhibition of viral-induced cytopathic effect by MTT method
[PMID: 18426195]
MT4 EC50
22 nM
Compound: 1, KNI-272
Antiviral activity against HIV1 3B in MT4 cells by MTT assay
Antiviral activity against HIV1 3B in MT4 cells by MTT assay
[PMID: 17537628]
分子量

667.84

Formula

C33H41N5O6S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Kynostatin 272 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kynostatin 272147318-81-8KNI 272 Kynostatin NSC 651714Kynostatin272Kynostatin-272KNI272KNI-272NSC651714NSC 651714NSC-651714HIV ProteaseHIVviral replicationAIDSinhibitorInhibitorinhibit

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