2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. L 743310

L 743310 是一种非肽类人类神经激肽 hNK1 受体的选择性拮抗剂，对灵长类和克隆的人 hNK1 受体具有高亲和力，而对啮齿类 NK1 受体的亲和力较低。L 743310 可抑制豚鼠食管中由树脂毒素引起的血浆蛋白外渗。L 743310 对顺铂引起的呕吐具有剂量依赖性的抑制作用。

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L 743310 Chemical Structure

L 743310 Chemical Structure

CAS No. : 187724-86-3

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L 743310 相关抗体

Top Publications Citing Use of Products

查看 Neurokinin Receptor 亚型特异性产品:

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NK1 NK2 NK3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L 743310 is a non-peptide, selective antagonist of the human neurokinin hNK1 receptor, with high affinity for primate and cloned human hNK1 receptors and lower affinity for rodent NK1 receptors. L 743310 inhibits resiniferatoxin-induced plasma protein extravasation in guinea pig esophagus. L 743310 has a dose-dependent inhibitory effect on cisplatin-induced emesis[1].

IC50 & Target

hNK1 receptor[1]
分子量

675.50

Formula

C30H33BrF6N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

L 743310 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L 743310187724-86-3L743310L-743310Neurokinin ReceptorNK receptorTachykinin receptorInhibitorinhibitorinhibit

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产品名称：
L 743310
目录号：
HY-117952
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