2. Anti-infection
  3. HBV
  4. Lagociclovir valactate

Lagociclovir valactate 是 Lagociclovir (HY-14844) 的前药。Lagociclovir valactate 是一种具有口服活性的抗 HBV 试剂。

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Lagociclovir valactate Chemical Structure

Lagociclovir valactate Chemical Structure

CAS No. : 1001670-19-4

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Lagociclovir valactate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lagociclovir valactate is a prodrug of Lagociclovir (HY-14844). Lagociclovir valactate is an orally active anti-HBV agent[1].

IC50 & Target

HBV[1]
体内研究
(In Vivo)

Lagociclovir valactate (20 or 60 mg/kg; p.o.; daily for 10 weeks) shows anti-woodchuck hepatitis virus (WHV) activity in woodchucks[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Woodchucks with chronic WHV infection[1]
Dosage: 20 or 60 mg/kg
Administration: Oral, daily for 10 weeks
Result: Reduced WHV viremia effectively and maintained WHV DNA at a very low level.
Animal Model: Woodchucks[1]
Dosage: 10 or 40 mg/kg
Administration: Oral (Pharmacokinetic Analysis)
Result: Average pharmacokinetic parameters for Lagociclovir after oral administration of Lagociclovir valactate to healthy and chronically WHV infected woodchucks[1]
Pharmacokinetic parameter for Lagociclovir Healthy woodchucks (n = 4) receiving Lagociclovir valactate at 10 mg/kg Healthy woodchucks (n = 4) receiving Lagociclovir valactate at 40 mg/kg WHV-infected woodchucks (n = 14) receiving Lagociclovir valactate at 60 mg/kg
Cmax (μM) 0.54 ± 0.14 2.10 ± 1.5 3.50 ± 1.9
Tmax (h) 4.10 ± 1.0 3.30 ± 1.5 2.90 ± 1.1
AUC0-∞ (μM • h/liter) 5.15 ± 1.0 10.50 ± 4.2 20.1 ± 11.3
t1/2 (h) 5.44 ± 1.2 4.20 ± 1.6 4.7 ± 0.8
分子量

454.45

Formula

C19H27FN6O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lagociclovir valactate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lagociclovir valactate1001670-19-4HBVHepatitis B virusLagociclovirWHVwoodchuck hepatitis virusInhibitorinhibitorinhibit

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产品名称：
Lagociclovir valactate
目录号：
HY-107026
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