2. Cytoskeleton
  3. Arp2/3 Complex
  4. Latrunculin A

Latrunculin A  (Synonyms: LAT-A)

目录号: HY-16929 纯度: ≥97.0%
COA 产品使用指南

摩尔计算器

Latrunculin A (LAT-A) 是一种 G-肌动蛋白聚合 (G-actin polymerization) 抑制剂，在红海海绵 Latrunculia magnifica 中发现的。Latrunculin A 能够与肌动蛋白 (actin) 单体结合，抑制其聚集，对 ATP-actin，ADP-Pi-actin，ADP-actin 和 G-actin 的 Kd 值分别为 0.1，0.4，4.7 μM 和 0.19 μM。Latrunculin A 具有有效的抗转移特性，可用于癌症的研究。Latrunculin A 抑制细胞迁移。

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Latrunculin A Chemical Structure

Latrunculin A Chemical Structure

CAS No. : 76343-93-6

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规格 价格 是否有货 数量
100 μg (237.2 μM * 1 mL in Ethanol) ￥4300
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Latrunculin A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration[1][2][3][4][5][6].

IC50 & Target

Kd: 0.1 μM (ATP-actin), 0.4 μM (ADP-Pi-actin), 4.7 μM (ADP-actin), 0.19 μM (G-actin)[2]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.06 μg/mL
Compound: 1
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 8350092]
HCT-116 IC50
1.1 μM
Compound: 1, NSC-613011
Cytotoxicity against human HCT116 cells after 3 days by trypan blue assay
Cytotoxicity against human HCT116 cells after 3 days by trypan blue assay
[PMID: 18942825]
HT-29 IC50
0.06 μg/mL
Compound: 1
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
[PMID: 8350092]
HT-29 IC50
0.08 μg/mL
Compound: 10
Antiproliferative activity against human HT-29 cells assessed as cell viability after 96 hrs by CellTiter-Glo luminescence assay
Antiproliferative activity against human HT-29 cells assessed as cell viability after 96 hrs by CellTiter-Glo luminescence assay
[PMID: 22129061]
MCF7 IC50
0.48 μM
Compound: 99a
Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 33940466]
MDA-MB-231 IC50
4.19 μM
Compound: 99a
Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 33940466]
MDA-MB-435 IC50
0.04 μg/mL
Compound: 10
Antiproliferative activity against human MDA-MB-435 cells assessed as cell viability after 96 hrs by CellTiter-Glo luminescence assay
Antiproliferative activity against human MDA-MB-435 cells assessed as cell viability after 96 hrs by CellTiter-Glo luminescence assay
[PMID: 22129061]
MDA-MB-435 IC50
2.8 μM
Compound: 1, NSC-613011
Cytotoxicity against human MDA-MB-435 cells 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-435 cells 48 hrs by SRB assay
[PMID: 18942825]
P388 IC50
4.1 μg/mL
Compound: 1
Cytotoxicity against mouse P388 cells after 48 hrs by MTT assay
Cytotoxicity against mouse P388 cells after 48 hrs by MTT assay
[PMID: 8350092]
T47D IC50
25 μM
Compound: 1,Latrunculin A
Inhibition of 1,10-phenanthroline-induced HIF1 activation in human T47D cells by cell based reporter gene assay
Inhibition of 1,10-phenanthroline-induced HIF1 activation in human T47D cells by cell based reporter gene assay
[PMID: 18298079]
T47D IC50
6.7 μM
Compound: 1,Latrunculin A
Inhibition of hypoxia-induced HIF1 activation in human T47D cells by cell based reporter gene assay
Inhibition of hypoxia-induced HIF1 activation in human T47D cells by cell based reporter gene assay
[PMID: 18298079]
U-937 IC50
0.07 μg/mL
Compound: 10
Antiproliferative activity against human U937 cells assessed as cell viability after 96 hrs by CellTiter-Glo luminescence assay
Antiproliferative activity against human U937 cells assessed as cell viability after 96 hrs by CellTiter-Glo luminescence assay
[PMID: 22129061]
体外研究
(In Vitro)

LatruncuLin A (50-1000 nM) 对人前列腺癌 PC-3M 细胞具有强效抗侵袭活性，可抑制 PC-3M-CT+ 球体解聚和细胞迁移[3]。
LatruncuLin A (3-30 μM) 抑制缺氧诱导的 HIF-1 激活，在人乳腺癌 T47D 细胞中的 IC50 值为 6.7 μM[3]。
LatruncuLin A (0-0.2 μM，4 小时) 在高浓度 (例如 0.2 μM) 下对人肝癌 HepG2 细胞中的 HuR 水平具有显著抑制作用，而在 0.02 μM 时仅抑制 HuR，但在高浓度下对人肝癌 Huh7 没有抑制作用cells[4]。
LatruncuLin A (0.1 μM，24 hours) 可导致细胞迁移显著减少，并对人肝癌细胞系 HepG2 的细胞增殖具有抑制作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Latrunculin A 相关抗体:
体内研究
(In Vivo)

LatruncuLin A (腹腔注射，0.05 mg/kg，前20天分3次给药，120天) 对感染腺癌 (MKN45) 或癌 (NugC-4) 的雄性BALB/c裸鼠模型具有较强的抗肿瘤作用[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c nude mice models infected with adenocarcinoma (MKN45) or carcinoma (NUGC-4)[5]
Dosage: 0.05 mg/kg
Administration: Intraperitoneal injection; three doses in the first 20 days; 120 days
Result: Extended the mean life expectancy to 23.5 days comparing to control of 16 days in adenocarcinoma (MKN45) mice and the mean survival time was 42 days comparing to untreated of 31 days in carcinoma (NUGC-4) mice.
Clinical Trial
分子量

421.55

Formula

C22H31NO5S
CAS 号
性状

液体

颜色

Colorless to light yellow

结构分类
初始来源

red sea sponge Latrunculia magnifica
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
纯度 & 产品资料

纯度: ≥98.0%

COA (270 KB)

产品使用指南 (1538 KB)
参考文献

Latrunculin A 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Latrunculin A76343-93-6LAT-AArp2/3 ComplexActin-related protein 2/3 complexG-actin inhibitorATP-actinADP-Pi-actinADP-actinanti-canceranti-metastaticInhibitorinhibitorinhibit

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