LB42908 

LB42908 is a potent, selective and orally active farnesyltransferase inhibitor. LB42908 inhibits farnesylation of H-Ras, K-Ras with IC₅₀ values of 0.9 nM, 2.4 nM for H-Ras, K-Ras, respectively. LB42908 shows antiproliferative activity. LB42908 shows antitumor activity^[1].

IC₅₀: 0.9 nM (H-Ras); 2.4 nM (K-Ras)^[1]

LB42908 显示出抗增殖活性，对 HT29、HCT116、A549、EJ 和 T24 细胞的 GI₅₀ 值分别为 4.5、17.6、1.2、0.56、0.45 nM^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LB42908 (20, 40, 60 mg/kg; p.o.; twice daily for 21 days) 以剂量依赖性方式抑制肿瘤生长^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

533.62

C₃₂H₃₁N₅O₃

226927-89-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lee H, et al. A novel class of highly potent, selective, and non-peptidic inhibitor of Ras farnesyltransferase (FTase). Bioorg Med Chem Lett. 2001 Dec 3;11(23):3069-72.  [Content Brief]