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  3. LBT-999

LBT-999 是一种用于正电子发射断层扫描(PET)探索多巴胺转运体(DAT)的苯基托烷衍生物,具有在体外对大鼠纹状体膜和人死后脑切片上与DAT高亲和力结合,在体内大鼠和狒狒模型中在纹状体有高摄取,且其结合可被特定化合物阻断等活性。

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LBT-999 Chemical Structure

LBT-999 Chemical Structure

CAS No. : 877467-20-4

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LBT-999 is a phenyltropane derivative used for positron emission tomography (PET) exploration of the dopamine transporter (DAT). It has high affinity binding to DAT on rat striatal membranes and human postmortem brain slices in vitro, high uptake in the striatum in rat and baboon models in vivo, and its binding can be blocked by specific compounds.

分子量

331.42

Formula

C20H26FNO2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

LBT-999 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
LBT-999
目录号:
HY-121810
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