2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. LCL-PEG3-N3 hydrochloride

LCL-PEG3-N3 (hydrochloride) 是一种诱饵寡核苷酸 E3 连接酶配体，可用于开发嵌合分子 LCL-ER(dec)，降解雌激素受体。LCL-PEG3-N3 (hydrochloride) 是一种点击化学试剂。它含有 Azide 基团，可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应（CuAAc)。它还可以和含有 DBCO 或 BCN 基团的分子发生环张力驱动的炔-叠氮环加成反应 (SPAAC)。

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LCL-PEG3-N3 hydrochloride Chemical Structure

LCL-PEG3-N3 hydrochloride Chemical Structure

CAS No. : 3033849-91-8

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LCL-PEG3-N3 hydrochloride 相关抗体

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

  • 生物活性

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生物活性

LCL-PEG3-N3 (hydrochloride) is a decoy oligonucleotide ligand for E3 ligase which can be used for developing chimeric molecules LCL-ER(dec), degrading the estrogen receptor[1]. LCL-PEG3-N3 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target

IAP

 

分子量

692.27

Formula

C32H46ClN7O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LCL-PEG3-N3 hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LCL-PEG3-N33033849-91-8E3 Ligase Ligand-Linker ConjugatesLCL-ERselectiveoligonucleotidedegraderubiquitin-proteasomeestrogen receptor αtranscriptionERαUPSTFsInhibitorinhibitorinhibit

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