2. PI3K/Akt/mTOR
  3. PDK-1
  4. LDHA/PDKs-IN-2

LDHA/PDKs-IN-2 (compound 20k) 是一种有效的 PDKs 和 LDHA 双重抑制剂，IC50s 分别为 1.6 和 0.7 μM。LDHA/PDKs-IN-2 减少 A549 细胞增殖，EC50 为 15.7 μM，减少乳酸形成，增加耗氧量。LDHA/PDKs-IN-2 具有研究癌症疾病的潜力。

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LDHA/PDKs-IN-2 Chemical Structure

LDHA/PDKs-IN-2 Chemical Structure

CAS No. : 2490699-44-8

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LDHA/PDKs-IN-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LDHA/PDKs-IN-2 (compound 20k) is a potent and dual inhibitor of PDKs and LDHA with IC50s of 1.6 and 0.7 μM, respectively. LDHA/PDKs-IN-2 reduces A549 cell proliferation with an EC50 of 15.7 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-2 has the potential for the research of cancer diseases[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 EC50
15.7 μM
Compound: 20k
Anticancer activity against human A549 assessed as cell growth inhibition measured after 72 hrs by MTT assay
Anticancer activity against human A549 assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 32688200]
分子量

332.35

Formula

C17H20N2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LDHA/PDKs-IN-2 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LDHA/PDKs-IN-22490699-44-8PDK-13-Phosphoinositide-dependent protein kinase 1PDKsLDHAproliferationlactateoxygen consumptioncancerInhibitorinhibitorinhibit

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