2. Immunology/Inflammation
  3. Interleukin Related
  4. Lebrikizumab

Lebrikizumab  (Synonyms: 来瑞组单抗; TNX-650)

目录号: HY-P99025 纯度: 99.90%
COA

摩尔计算器

Lebrikizumab (TNX-650) 是一种 IgG4 人源化的抗白细胞介素-13 (IL-13) 单克隆抗体，具有抗瘙痒的效果，能够特异性结合到 IL-13 的非受体结合域，并抑制其功能。Lebrikizumab 抑制 IL-13 驱动的 Th2 炎症反应，并阻断 IL-4Rα/IL-13Rα1 的信号传导。Lebrikizumab 可用于哮喘、特应性皮炎和神经炎症性疾病的研究。

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CAS No. : 953400-68-5

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规格 价格 是否有货 数量
1 mg ￥3000
In-stock
5 mg ￥7800
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Lebrikizumab 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lebrikizumab (TNX-650) is an IgG4 humanized anti-interleukin-13 (IL-13) mAb with anti-itch effects that specifically binds to IL-13 in a non-receptor binding domain and inhibits its function. Lebrikizumab inhibits the IL-13 driven Th2 inflammatory response and blocks the signaling of IL-4Rα/IL-13Rα1. Lebrikizumab can be used for the research of asthma, atopic dermatitis and neuroinflammatory diseases[1][2][3].

IC50 & Target

IL-13

 

体外研究
(In Vitro)

Lebrikizumab (500 μg/mL 或 1 mg/mL，24 小时) 在体外有效抑制了 IL-13 引发的神经敏感反应对每种三种瘙痒物质的反应[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lebrikizumab 相关抗体:
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

来瑞组单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Loaded IL-13 Protein, Human (HEK293, His, HY-P70568) on AHC2 biosensor, can bind Lebrikizumab with an affinity constant of 7.283E-10 M as determined in BLI assay.
纯度 & 产品资料

纯度: 99.90%

COA (172 KB) SDS-PAGE (79 KB) SEC-HPLC (182 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Lebrikizumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lebrikizumab953400-68-5TNX-650来瑞组单抗TNX650TNX 650Interleukin RelatedILIgG4IL-13anti-itch effectsTh2 inflammatory responseIL-4Rα/IL-13Rα1asthmaatopic dermatitisneuroinflammatory diseasesInhibitorinhibitorinhibit

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