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  5. [Leu144,Arg147]-PLP (139-151)

[Leu144,Arg147]-PLP (139-151) 

目录号: HY-P10456
产品使用指南

摩尔计算器

[Leu144,Arg147]-PLP (139-151) 是髓鞘蛋白脂蛋白 (PLP) 的一种突变肽片段，在第 144 位和第 147 位上的色氨酸和组氨酸分别被亮氨酸和精氨酸取代。[Leu144,Arg147]-PLP (139-151) 同时还作为脑脊髓炎 Th1 克隆的 T 细胞受体 (TCR) 拮抗剂，在体外阻断其激活。[Leu144,Arg147]-PLP (139-151) 还能抑制实验性自身免疫性脑脊髓炎 (EAE) 发展。

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Custom Peptide Synthesis

[Leu144,Arg147]-PLP (139-151) Chemical Structure

[Leu144,Arg147]-PLP (139-151) Chemical Structure

CAS No. : 188859-65-6

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[Leu144,Arg147]-PLP (139-151) 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

[Leu144,Arg147]-PLP (139-151) is a mutant peptide fragment of myelin proteolipid protein (PLP), with the tryptophan and histidine at positions 144 and 147 respectively replaced by leucine and arginine. [Leu144,Arg147]-PLP (139-151) also serves as a T cell receptor (TCR) antagonist for encephalitogenic Th1 clones, blocking their activation in vitro. Furthermore, [Leu144,Arg147]-PLP (139-151) can inhibit the development of experimental autoimmune encephalomyelitis (EAE)[1].

IC50 & Target

T cell receptor(TCR)[1].
分子量

1467.71

Formula

C67H110N20O17
CAS 号
Sequence

His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe
Sequence Shortening

HSLGKLLGRPDKF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

[Leu144,Arg147]-PLP (139-151) 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[Leu144,Arg147]-PLP (139-151)188859-65-6Othersexperimental autoimmune encephalomyelitis (EAE)proteolipid protein (PLP)mutant peptideencephalitogenic Th1 clonesInhibitorinhibitorinhibit

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