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  4. Lipid-lowering agent-1

Lipid-lowering agent-1 是一种有效的降脂剂。Lipid-lowering agent-1 具有显著的抑制低密度脂蛋白胆固醇 (LDLC) 和促进高密度脂蛋白胆固醇 (HDLC) 产生的药理作用。Lipid-lowering agent-1 对高脂饮食大鼠有显著的降脂作用。

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Lipid-lowering agent-1 Chemical Structure

Lipid-lowering agent-1 Chemical Structure

CAS No. : 2304859-34-3

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Lipid-lowering agent-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lipid-lowering agent-1 is a potent lipid-lowering agent. Lipid-lowering agent-1 has significant pharmacological effects on the inhibition of low-density lipoprotein cholesterol (LDLC) and promotion of high-density lipoprotein cholesterol (HDLC) production. Lipid-lowering agent-1 shows potent hypolipidemic effect in high-fat diet rats[1].

体外研究
(In Vitro)

Lipid-lowering agent-1 (compound 1m) (12.5 μM; 72 hours) does not exhibit significant toxicity to both HepG2 and 3T3-L1 cells at a high concentration[1].
Lipid-lowering agent-1 (10 μM; 24 hours) has significant pharmacological effects on the inhibition of LDLC and promotion of HDLC production[1].
Lipid-lowering agent-1 (10 μM; 24 hours) inhibits the conversion of 3T3-L1 cells from pre-adipose to adipose-like with the inhibition of triglycerides (TG) by 70.4%[1].
Lipid-lowering agent-1 (10 μM; 10 days) decreases yellow lipid droplets effectively in 3T3-L1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lipid-lowering agent-1 相关抗体:

Cell Cytotoxicity Assay

Cell Line: HepG2 and 3T3-L1[1]
Concentration: 12.5 μM
Incubation Time: 72 hours
Result: Did not exhibit significant toxicity to both HepG2 and 3T3-L1 cells at a high concentration.

Cell Differentiation Assay

Cell Line: 3T3-L1 cells[1]
Concentration: 10 μM
Incubation Time: 24 hours
Result: Inhibited the conversion of 3T3-L1 cells from pre-adipose to adipose-like with the inhibition of triglycerides (TG) by 70.4%
体内研究
(In Vivo)

Lipid-lowering agent-1 (15 mg/kg; i.g., daily for 40 or 80 days) reduces blood cholesterolby, triglycerides and LDLC by 19.6%, 34.52%, and 41.49% after dosing 40 days, moreover the three indexes is still better than that of berberine after dosing 80 days[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High-fat diet (HFD) rats[1]
Dosage: 15 mg/kg
Administration: i.g., daily for 40 or 80 days
Result: Reduced blood cholesterolby, triglycerides and LDLC by 19.6%, 34.52%, and 41.49% after dosing 40 days, moreover the three indexes was still better than that of berberine after dosing 80 days.
分子量

565.95

Formula

C26H19ClF3NO6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lipid-lowering agent-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lipid-lowering agent-12304859-34-3OthersBerberineHypolipidemic activityTotal cholesterolTriglycerideLow-density lipoprotein cholesterolHigh-density lipoprotein cholesterolInhibitorinhibitorinhibit

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