Liriodenine (Synonyms: Spermatheridine; VLT045)

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Liriodenine (Spermatheridine;VLT045) 是从植物 Mitrephora sirikitiae 中分离出来的，具有抗癌活性。Liriodenine 诱导细胞凋亡 (apoptosis)，通过诱导 caspase-3 和 caspase-9 激活其内在通路。

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Liriodenine Chemical Structure

CAS No. : 475-75-2

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生物活性
纯度 & 产品资料
参考文献

生物活性

Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant?Mitrephora sirikitiae?and has anti-cancer activities^[1]. Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9^[2].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
B16-F10	IC₅₀	> 10 μM Compound: 20	Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay	[PMID: 27300257]
BV-2	IC₅₀	5 μM Compound: 13	Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess assay Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess assay	[PMID: 33822610]
HepG2	IC₅₀	8.3 μM Compound: 20	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay	[PMID: 27300257]
HL-60	IC₅₀	5.5 μM Compound: 20	Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay	[PMID: 27300257]
HT-29	IC₅₀	> 10 μM Compound: 6	Cytotoxicity against human HT-29 cells assessed as inhibition of cell proliferation after 3 days by SRB assay Cytotoxicity against human HT-29 cells assessed as inhibition of cell proliferation after 3 days by SRB assay	[PMID: 23327794]
K562	IC₅₀	5 μM Compound: 20	Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay	[PMID: 27300257]
KB	IC₅₀	5 μM Compound: 9	Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay	[PMID: 19874044]
MCF7	IC₅₀	5 μM Compound: 9	Cytotoxicity against human MCF7 cells after 3 days by sulforhodamine B assay Cytotoxicity against human MCF7 cells after 3 days by sulforhodamine B assay	[PMID: 19874044]
NCI-H460	IC₅₀	5 μM Compound: 9	Cytotoxicity against human NCI-H460 cells after 3 days by sulforhodamine B assay Cytotoxicity against human NCI-H460 cells after 3 days by sulforhodamine B assay	[PMID: 19874044]
PBMC	IC₅₀	34.8 μM Compound: 20	Cytotoxicity against human PBMC cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay Cytotoxicity against human PBMC cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay	[PMID: 27300257]
RAW264.7	IC₅₀	1.39 μM Compound: 129	Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay	[PMID: 33454546]
RAW264.7	IC₅₀	10.5 μM Compound: 10	Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess reagent based assay Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess reagent based assay	[PMID: 33939429]
RAW264.7	IC₅₀	34.7 μM Compound: 6	Inhibition of LPS-stimulated nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay Inhibition of LPS-stimulated nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay	[PMID: 32247751]
SF-268	IC₅₀	5 μM Compound: 9	Cytotoxicity against human SF268 cells after 3 days by sulforhodamine B assay Cytotoxicity against human SF268 cells after 3 days by sulforhodamine B assay	[PMID: 19874044]

体外研究
(In Vitro)

Liriodenine is against P-388, KB, HT-29, MCF-7, A549, ASK and Hek-293 cells with IC₅₀ values of 9.60 μM, 11.02 μM, 10.62 μM, 9.20 μM and 8.07μM, respectively.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

275.26

Formula

C₁₇H₉NO₃

CAS 号

475-75-2

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Natthinee Anantachoke, et al. Cytotoxic Compounds From the Leaves and Stems of the Endemic Thai Plant Mitrephora sirikitiae. Pharm Biol [Content Brief]

[2]. Noraziah Nordin, et al. Liriodenine, an Aporphine Alkaloid From Enicosanthellum Pulchrum, Inhibits Proliferation of Human Ovarian Cancer Cells Through Induction of Apoptosis via the Mitochondrial Signaling Pathway and Blocking Cell Cycle Progression. Drug Des Devel Ther [Content Brief]

Liriodenine 相关分类

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Liriodenine (Synonyms: Spermatheridine; VLT045)

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Liriodenine (Synonyms: Spermatheridine; VLT045)

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