Liriodenine  (Synonyms: Spermatheridine; VLT045)

Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant?Mitrephora sirikitiae?and has anti-cancer activities^[1]. Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9^[2].

Liriodenine is against P-388, KB, HT-29, MCF-7, A549, ASK and Hek-293 cells with IC₅₀ values of 9.60 μM, 11.02 μM, 10.62 μM, 9.20 μM and 8.07μM, respectively.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

275.26

C₁₇H₉NO₃

475-75-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Natthinee Anantachoke, et al. Cytotoxic Compounds From the Leaves and Stems of the Endemic Thai Plant Mitrephora sirikitiae. Pharm Biol  [Content Brief]

  [2]. Noraziah Nordin, et al. Liriodenine, an Aporphine Alkaloid From Enicosanthellum Pulchrum, Inhibits Proliferation of Human Ovarian Cancer Cells Through Induction of Apoptosis via the Mitochondrial Signaling Pathway and Blocking Cell Cycle Progression. Drug Des Devel Ther  [Content Brief]