2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Lorvotuzumab mertansine

Lorvotuzumab mertansine  (Synonyms: IMGN-901; BB-1090)

目录号: HY-132262
产品使用指南

摩尔计算器

Lorvotuzumab mertansine 是一种 ADC，由抗 CD56的人源化 N901 单克隆抗体组成，通过稳定的二硫连接剂与 maytansinoid DM1 结合。Lorvotuzumab mertansine 具有抗肿瘤活性。

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Lorvotuzumab mertansine Chemical Structure

Lorvotuzumab mertansine Chemical Structure

CAS No. : 1008106-64-6

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Lorvotuzumab mertansine 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lorvotuzumab mertansine is an ADC consisting of a humanized N901 monoclonal antibody against CD56 bound to maytansinoid DM1 via a stable disulfide linker. Lorvotuzumab mertansine has antitumor activity[1].

体外研究
(In Vitro)

Lorvotuzumab mertansine（0.001-100 nM，8 天）对这两个细胞系显示出靶向细胞杀伤活性，作用于 NCI-H526 细胞系的 IC50值为0.2 nM，NCI-H69 细胞系为 5 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lorvotuzumab mertansine 相关抗体:
体内研究
(In Vivo)

Lorvotuzumab mertansine（3-51 mg/kg，静脉注射，一次）在 CB.17 SCID 小鼠 SW2 SCLC 异种移植肿瘤中具有强大的抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SW2 SCLC xenograft tumor CB.17 SCID mice
Dosage: 3、17 and 51 mg/kg
Administration: i.v., once
Result: Showed high anti-tumor activity at a dose of 17 mg/kg with half of the animals being tumor free and complete tumor regression at a dose of 51 mg/kg.
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lorvotuzumab mertansine 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lorvotuzumab mertansine1008106-64-6IMGN-901 BB-1090IMGN901IMGN 901BB1090BB 1090BB-1090Antibody-Drug Conjugates (ADCs)Antibody-Drug ConjugatesCD56N901DM1antitumorInhibitorinhibitorinhibit

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