LQB-118 

LQB-118 is an orally active compound derived from sandalwood. LQB-118 can inhibit the migration of glioblastoma cells and induce cell death. LQB-118 can suppress the migration and invasion of prostate cancer cells by regulating the AKT/GSK3β pathway and the expression of the MMP-9/reck genes. LQB-118 can also inhibit yeast polysaccharide-induced inflammation both in vivo and in vitro. Additionally, LQB-118 selectively induces ROS-triggered and mitochondrial-dependent apoptosis in Leishmania amazonensis. LQB-118 can be used in studies related to inflammation, infections, and cancer diseases^[1][2][3][4].

304.30

C₁₉H₁₂O₄

1219104-20-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bernardo PS, et al. LQB‑118 compound inhibits migration and induces cell death in glioblastoma cells. Oncol Rep. 2020 Jan;43(1):346-357.  [Content Brief]

  [2]. Martino T, et al. LQB-118 Suppresses Migration and Invasion of Prostate Cancer Cells by Modulating the Akt/GSK3β Pathway and MMP-9/Reck Gene Expression. Anticancer Res. 2023 Jan;43(1):359-367.  [Content Brief]

  [3]. Lima ÉA, et al. The pterocarpanquinone LQB 118 inhibits inflammation triggered by zymosan in vivo and in vitro. Int Immunopharmacol. 2020 Jun;83:106399.  [Content Brief]

  [4]. Ribeiro GA, et al. LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis. J Antimicrob Chemother. 2013 Apr;68(4):789-99.  [Content Brief]