2. Epigenetics
  3. Histone Demethylase
  4. LSD1-IN-13 hydrochloride

LSD1-IN-13 hydrochloride (compound 7e) 是一种口服有效的 LSD1 抑制剂，其 IC50 值为 24.43 nM。LSD1-IN-13 hydrochloride 可激活 CD86 表达，其 EC50 值为 470 nM。LSD1-IN-13 hydrochloride 诱导 AML (急性髓系白血病)细胞系分化。

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LSD1-IN-13 hydrochloride Chemical Structure

LSD1-IN-13 hydrochloride Chemical Structure

CAS No. : 2170347-90-5

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Other Forms of LSD1-IN-13 hydrochloride:

LSD1-IN-13 hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Histone Demethylase 亚型特异性产品:

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KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LSD1-IN-13 hydrochloride (compound 7e) is an orally active and potent LSD1 inhibitor, with an IC50 of 24.43 nM. LSD1-IN-13 hydrochloride can activate CD86 expression, with an EC50 of 470 nM. LSD1-IN-13 hydrochloride induces differentiation of AML (acute myeloid leukemia) cell lines[1].

IC50 & Target

KDM1/LSD1

 

体外研究
(In Vitro)

LSD1-IN-13 hydrochloride (compound 7e) shows good selectivity over LSD2 (205-fold) and MAOs (>4000-fold)[1].
LSD1-IN-13 hydrochloride shows potent and selective antiproliferative activity in MV-4-11, with an IC50 of 1.36 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LSD1-IN-13 hydrochloride 相关抗体:
体内研究
(In Vivo)

LSD1-IN-13 hydrochloride (compound 7e) (MV-4-11 xenograft mice, 0-20 mg/kg, Orally, daily for 15 days) suppresses tumor growth significantly in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

448.02

Formula

C23H30ClN3O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LSD1-IN-13 hydrochloride 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSD1-IN-132170347-90-5Histone Demethylaseorally activeMV-4-11 cell linesacute myeloid leukemiapiperidine derivativeantitumor activityInhibitorinhibitorinhibit

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产品名称：
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目录号：
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