2. Epigenetics Apoptosis
  3. Histone Demethylase Apoptosis
  4. LSD1-IN-36

LSD1-IN-36 是一种有效的 LSD1 抑制剂，IC50 值为 0.8 nM。LSD1-IN-36 诱导细胞凋亡 (apoptosis) 并阻止细胞周期。LSD1-IN-36 显示出抗肿瘤活性。

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LSD1-IN-36 Chemical Structure

LSD1-IN-36 Chemical Structure

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LSD1-IN-36 相关抗体

Top Publications Citing Use of Products

查看 Histone Demethylase 亚型特异性产品:

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KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LSD1-IN-36 is a potent LSD1 inhibitor with an IC50 value of 0.8 nM. LSD1-IN-36 induces apoptosis and arrests the cell cycle. LSD1-IN-36 shows antitumor activity[1].

IC50 & Target[1]

LSD1

0.8 nM (IC50)

体外研究
(In Vitro)

LSD1-IN-36 (compound 10e) 在几种人类肿瘤细胞系中表现出显著的抑制作用。它对 HCT116 细胞、MCF-7、A549 和 MDA-MB-231 表现出很强的活性，IC50 值分别为 0.1 μM、0.1 μM、0.3 μM 和 0.8 μM[1]。
LSD1-IN-36（0.125-0.5 μM；72 小时）在所有给药浓度下均对 HCT116 克隆的形成表现出显著的抑制作用[1]。
LSD1-IN-36（0.125-0.5 μM；72 小时）诱导细胞凋亡并阻止细胞周期[1]。
LSD1-IN-36（0.125-0.5 μM；72 小时）增加 HCT116 中 H3K9me2、H3K9me1、H3K4me2 和 H3K4me1 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LSD1-IN-36 相关抗体:

Cell Cycle Analysis[1]

Cell Line: HCT116 cells
Concentration: 0.125 μM, 0.25 μM, 0.5 μM
Incubation Time: 72 hours
Result: Induced cell apoptosis in HCT116.

Apoptosis Analysis[1]

Cell Line: HCT116 cells
Concentration: 0.125 μM, 0.25 μM, 0.5 μM
Incubation Time: 72 hours
Result: Induced cell apoptosis in HCT116.

Western Blot Analysis[1]

Cell Line: HCT116 cells
Concentration: 0.125 μM, 0.25 μM, 0.5 μM
Incubation Time: 72 hours
Result: Increased the expression of H3K9me2 and H3K9me1 in HCT116.
体内研究
(In Vivo)

LSD1-IN-36（compound 10e；60 mg/kg；IP；每日；持续 3 周）在体内表现出显著的肿瘤抑制率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NOD-SCID mice injected with HCT116 cells[1]
Dosage: 60 mg/kg
Administration: IP; daily; for 3 weeks
Result: Showed substantial growth inhibition of tumors.
分子量

459.52

Formula

C22H25N3O6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LSD1-IN-36 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSD1-IN-36Histone DemethylaseApoptosisLSD1 inhibitorantitumor activityapoptosiscell cycleH3K9me2H3K9me1Inhibitorinhibitorinhibit

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目录号：
HY-168504
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