2. Metabolic Enzyme/Protease
  3. Aminopeptidase
  4. LTA4H-IN-4

LTA4H-IN-4 (compound 3) 是一个口服活性 LTA4H 抑制剂。LTA4H-IN-4 对 hERG 的 IC50 值为 156 μM。LTA4H-IN-4 可用于炎症相关研究。

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LTA4H-IN-4 Chemical Structure

LTA4H-IN-4 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

LTA4H-IN-4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LTA4H-IN-4 (compound 3) is an orally active LTA4H inhibitor. The IC50 value of LTA4H-IN-4 for hERG is 156 μM. LTA4H-IN-4 can be used in inflammation related studies[1].

IC50 & Target

LTA4H

 

hERG

156 μM (IC50)

体外研究
(In Vitro)

LTA4H-IN-4 (compound 3) (0-10 μM, 4 h) 完全抑制钙离子载体刺激后的原代外周血单核细胞 (PBMCs) 中 LTB4 释放[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LTA4H-IN-4 相关抗体:
体内研究
(In Vivo)

LTA4H-IN-4 (compound 3) (每天 2 次 0-300 mg/kg，间隔 10 小时，持续 7 天， i.v. or p.o.) 在小鼠关节炎模型、大鼠、狗中表现出明显的口服活性，且动物体重没有明显变化，毒理学研究中没有发现明显的不良结果[1]。

大鼠、小鼠和狗体内的药代动力学分析[1]

Animal model Route Dose (mg/kg) CL (mL/min kg) Vss (L/kg) MRT (h) AUCp.o. d.n.(nM·h) Cmax d.n. (nM) BAV (%)
mice i.v. 1 13 7.2 8.9 / / /
mice p.o. 10 / / / 1476 307 42
rats i.v. 1 21 6.3 5.0 / / /
rats p.o. 3 / / / 2200 175 97
rats p.o. 30 / / / 1773 198 78
rats p.o. 300 / / / 1741 87 77
dogs i.v. 0.1 6.6 13 20 / / /
dogs p.o. 0.1 / / / 6020 610 86
dogs p.o. 1 / / / 6655 859 95
dogs p.o. 10 / / / 7113 1157 102

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

351.40

Formula

C19H21N5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LTA4H-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LTA4H-IN-4AminopeptidaseInflammationC57BL/6 miceWistar ratsBeagle dogsPharmacokineticsPharmacodynamicsInhibitorinhibitorinhibit

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目录号：
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