2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. LU-32-176B

LU-32-176B 是一种 GABA transporter 1(GAT1) 选择性抑制剂，与 GAT2 转运抑制剂 EF1502 具有协同抗惊厥作用。LU-32-176B 抑制 neurons、astrocytes 和 mGAT1，IC50 值分别为 2μM，1μM 和 4μM。

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LU-32-176B Chemical Structure

LU-32-176B Chemical Structure

CAS No. : 770688-66-9

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LU-32-176B 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively[1][2].

IC50 & Target

LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively[1][2].
体内研究
(In Vivo)

LU-32-176B (i.p.) and EF1502 can prevent sound-induced seizures in the Frings AGS-susceptible mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

398.45

Formula

C23H24F2N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LU-32-176B 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LU-32-176B770688-66-9GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorsynergistic anticonvulsant actionGAT2EF1502neuronsastrocytesmGAT1Inhibitorinhibitorinhibit

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产品名称：
LU-32-176B
目录号：
HY-118207
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