LUF7244 

LUF7244 is a selective allosteric modulator of K_v11.1 channels. LUF7244 inhibits early afterdepolarizations. LUF7244 can be used for anti-arrhythmia research^[1].

LUF7244 (0-10 μM; HEK293 cells) binds K_v11.1 channels and increases I_Kv11.1 by inhibiting inactivation in a dose-dependent manner^[1].
LUF7244 (0-10 μM; cardiomyocytes) reduces action potential duration (APD) by approximately 50% and dofetilide-induced early afterdepolarization (EAD) in isolated ventricular CMCs from SR and CAVB dogs^[1].
LUF7244 (10 μM) had no effects on I_KIR2.1, I_Nav1.5, I_Ca-L, and I_Ks but doubled I_Kr^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LUF7244 (2.5 mg/kg; i.v.; for 15 min) decreases repolarization parameters. LUF7244 has antiarrhythmic effects against dofetilide-induced TdP arrhythmias in CAVB dogs^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

366.80

C₂₀H₁₅ClN₂O₃

1821638-43-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Qile M, et, al. LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model. Br J Pharmacol. 2019 Oct;176(19):3871-3885.  [Content Brief]