2. Membrane Transporter/Ion Channel
  3. SGLT
  4. Luseogliflozin hydrate

Luseogliflozin hydrate  (Synonyms: TS 071 hydrate)

目录号: HY-10449A 纯度: 99.20%
COA 产品使用指南

摩尔计算器

Luseogliflozin (TS 071) hydrate 是一种选择有效的,具有口服活性的第二代钠-葡萄糖协同转运蛋白 2 (SGLT2) 抑制剂，IC50 为 2.26 nM。Luseogliflozin hydrate 可用于 2 型糖尿病的研究。

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Luseogliflozin hydrate Chemical Structure

Luseogliflozin hydrate Chemical Structure

CAS No. : 1152425-66-5

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5 mg ￥9800
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Other Forms of Luseogliflozin hydrate:

Luseogliflozin hydrate 相关抗体

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SGLT1 SGLT2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Luseogliflozin (TS 071) hydrate is a selective potent and orally active second-generation sodium-glucose co-transporter 2 (SGLT2) inhibitor with an IC50 of 2.26 nM. Luseogliflozin hydrate can be used for the research of type 2 diabetes mellitus (T2DM)[1][2].

IC50 & Target

SGLT2

 

体外研究
(In Vitro)

Luseogliflozin can increase beta cell proliferation through the activation of the FoxM1/PLK1/CENP-A pathway via humoral factors thats act in an insulin/IGF-1 receptor-independent manner. Luseogliflozin increases beta cell proliferation in OSI-906-treated mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Luseogliflozin hydrate 相关抗体:

Cell Viability Assay[2]

Cell Line: βIRKO, IRS1KO and IRS2KO beta cells
Concentration: 100 nM
Incubation Time: 24 and 48 hours
Result: Cell Viability Assay[2] Treating cells with serum from the OSI-906 (200 nM) or OSI-906+Luseogliflozin(100 nM) group led to significantly increased cell viability in the latter group in the control, IRS1KO, IRS2KO, as well as the insulin receptor (IR)-deficient βIRKO beta cells.
体内研究
(In Vivo)

SGLT2 inhibition with Luseogliflozin (10 mg/kg/daily; oral gavage) significantly ameliorates hyperglycaemia, but not hyperinsulinaemia, in the OSI-906(45 mg/kg)-treated mice. Luseogliflozin ameliorates hyperglycaemia induced by OSI-906[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J male mice aged 8 weeks old[2]
Dosage: 10 mg/kg/daily
Administration: Oral gavage; for 7 days between 08:00 and 09:00 hours
Result: Treatment significantly ameliorated the OSI-906 (45 mg/kg)-induced hyperglycaemia.
Clinical Trial
分子量

452.56

Formula

C23H32O7S
CAS 号
性状

固体

颜色

White to off-white

中文名称

鲁格列净水合物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料
参考文献

Luseogliflozin hydrate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Luseogliflozin1152425-66-5TS 071鲁格列净水合物TS071TS-071SGLTSodium-dependent glucose cotransportersSGLT2,sodiumglucoseco-transporterSGLT2diabetesmellitusInhibitorinhibitorinhibit

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目录号：
HY-10449A
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