2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. LXR
  4. LXRβ agonist-3

LXRβ agonist-3 (compound 4-13) 是一种强效的选择性 LXRβ (肝 X 受体 β) 激动剂，其 EC50 为 0.095 μM。LXRβ agonist-3 能有效抑制 U87EGFRvIII 细胞，其 IC50 为 3.75 μM。LXRβ agonist-3 具有抗肿瘤活性，对恶性胶质瘤有抑制作用。

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LXRβ agonist-3 Chemical Structure

LXRβ agonist-3 Chemical Structure

CAS No. : 2413308-63-9

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LXRβ agonist-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LXRβ agonist-3 (compound 4-13) is a potent and selective LXRβ (liver X receptor β) agonist, with an EC50 of 0.095 μM. LXRβ agonist-3 efficiently inhibits U87EGFRvIII cell, with an IC50 of 3.75 μM. LXRβ agonist-3 shows antitumor activity, and can inhibit glioblastoma[1].

IC50 & Target

EC50: 0.095 ± 0.012 μM (LXRβ) 0.277 ± 0.066 μM (LXRα)[1]
体内研究
(In Vivo)

LXRβ agonist-3 (compound 4-13) (BALB/c mice, 50 mg/kg, IP, daily for 15 days) significantly reduces glioblastoma tumor growth[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

563.66

Formula

C30H33N3O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LXRβ agonist-3 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LXRβ agonist-32413308-63-9LXRβ agonist3LXRβ agonist 3LXRLiver X receptorglioblastoma inhibitorU87EGFRvIII cellantitumor activityNuclear receptorInhibitorinhibitorinhibit

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