1. Neuronal Signaling Stem Cell/Wnt
  2. γ-secretase
  3. LY3056480

LY3056480 是γ-分泌酶 (γ-secretase) 抑制剂 (GSI),抑制 Notch 信号传导。LY3056480 可改善对轻度至中度感音神经性听力损失,并具有良好的安全和耐受性。LY3056480 通过鼓室内给药,可诱导哺乳动物毛细胞再生和部分听力恢复。

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LY3056480 Chemical Structure

LY3056480 Chemical Structure

CAS No. : 2064292-78-8

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LY3056480 is a gamma-secretase inhibitor (GSI) that inhibits Notch signaling. LY3056480 improves mild to moderate sensorineural hearing loss and is safe and tolerable. Intratympanic administration of LY3056480 induces hair cell regeneration and partial hearing recovery in mammals[1].

分子量

467.48

Formula

C23H28F3N3O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
LY3056480
目录号:
HY-158012
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