2. 天然产物
  3. 疾病研究领域 植物 生物碱
  4. 芸香科 炎症/免疫 吲哚类生物碱 咔唑生物碱
  5. 调料九里香 九里香
  6. Mahanimbine

Mahanimbine 是Murraya koenigii中的一种具有口服活性的生物碱。Mahanimbine 抑制高脂饮食 (HFD) 诱导的小鼠代谢并发症的进展。

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Mahanimbine Chemical Structure

Mahanimbine Chemical Structure

CAS No. : 21104-28-9

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规格 价格 是否有货
1 mg ￥11750
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Mahanimbine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mahanimbine is an orally active alkaloid from Murraya koenigii. Mahanimbine inhibits progression of high-fat diet (HFD)-induced metabolic complications in mice[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
B16-4A5 IC50
1.4 μM
Compound: 6
Inhibition of theophylline-induced melanogenesis in mouse B16-4A5 cells after 72 hrs by spectrophotometric analysis relative to control
Inhibition of theophylline-induced melanogenesis in mouse B16-4A5 cells after 72 hrs by spectrophotometric analysis relative to control
[PMID: 23376010]
体内研究
(In Vivo)

Mahanimbine (2-4 mg/kg; p.o.; daily for 12 weeks) prevents HFD-induced weight gain in mice (male and female)[1].
Mahanimbine prevented HFD-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress[1].
Mahanimbine treatment improves glucose clearance and upregulates the expression of insulin responsive genes in liver and adipose tissue[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino mice (7-8 weeks old, both sex)[1]
Dosage: HFD+LD (2 mg/kg of body weight of mahanimbine), HFD+HD (4 mg/kg of body weight of mahanimbine);
Administration: Oral suspension; daily for 12 weeks
Result: Male HFD+LD and HFD+HD groups showed 51.70±6 3.59% and 47.37±3.73% weight gain, respectively, as compared with 71.02±6 6.04% in HFD fed mice whereas female HFD+LD and HFD+HD groups showed 24.31±1.68% and 25.10±2.61% weight gain as compared with HFD group with 36.69±3.60% of weight gain.
分子量

331.45

Formula

C23H25NO
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mahanimbine 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mahanimbine21104-28-9Othershigh-fat dietmetabolicalkaloidinflammatoryinsulinglucoseclearanceInhibitorinhibitorinhibit

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