2. Neuronal Signaling
  3. Monoamine Oxidase
  4. MAO-B-IN-19

MAO-B-IN-19) 是一种选择性 MAO-B 抑制剂，IC50 为 0.67 μM。MAO-B-IN-19 显示出神经保护和抗炎特性。

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MAO-B-IN-19 Chemical Structure

MAO-B-IN-19 Chemical Structure

CAS No. : 152897-41-1

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MAO-B-IN-19 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MAO-B-IN-19 is a selective MAO-B inhibitor with an IC50 of 0.67 μM. MAO-B-IN-19 shows neuroprotective and anti-inflammatory properties[1].

IC50 & Target[1]

MAO-B

0.67 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
20.5 μM
Compound: 3m
Cytotoxicity against human HCT116 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 23771043]
HeLa IC50
22.6 μM
Compound: 1e, 1PF
Cytotoxicity against human HeLa cells assessed as decrease in cell survival after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as decrease in cell survival after 72 hrs by MTT assay
[PMID: 23501110]
K562 IC50
17.9 μM
Compound: 1e, 1PF
Cytotoxicity against human K562 cells assessed as decrease in cell survival after 72 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as decrease in cell survival after 72 hrs by MTT assay
[PMID: 23501110]
MCF7 IC50
26 μM
Compound: 1e, 1PF
Cytotoxicity against human MCF7 cells assessed as decrease in cell survival after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell survival after 72 hrs by MTT assay
[PMID: 23501110]
PC-3 IC50
30.4 μM
Compound: 1e, 1PF
Cytotoxicity against human PC3 cells assessed as decrease in cell survival after 72 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as decrease in cell survival after 72 hrs by MTT assay
[PMID: 23501110]
RAW264.7 IC50
> 10 μM
Compound: 12
Inhibition of LPS-stimulated ROS production in mouse RAW264.7 cells preincubated for 1 hr followed by LPS stimulation for 24 hrs measured after 30 mins by CMH2DCFDA probe-based fluorescence assay
Inhibition of LPS-stimulated ROS production in mouse RAW264.7 cells preincubated for 1 hr followed by LPS stimulation for 24 hrs measured after 30 mins by CMH2DCFDA probe-based fluorescence assay
[PMID: 28159411]
体外研究
(In Vitro)

MAO-B-IN-19（化合物 3f）显着抑制自身诱导的 Aβ1-42 聚集，并对 Aβ25-35 诱导的 PC12 细胞损伤显示出显着的神经保护作用。MAO-B-IN-19 是一种选择性金属螯合剂，可以抑制 Cu2+ 诱导的 Aβ1-42 聚集[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-19 相关抗体:
分子量

242.25

Formula

C15H11FO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MAO-B-IN-19 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-19152897-41-1Monoamine OxidaseMAOMAO-Banti-inflammatory propertyneuroprotectiveInhibitorinhibitorinhibit

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目录号：
HY-W335927
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