2. Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. Ser/Thr Protease Potassium Channel
  4. MASP-2-IN-1

MASP-2-IN-1 (Compound 77) 是甘露聚糖结合凝集素相关丝氨酸蛋白酶 (mannan-binding lectin-associated serine protease，MASP) 的抑制剂，可抑制 MASP2 和 MASP3，IC50 分别为 11.4 nM 和 13.2 µM。MASP-2-IN-1 对 hERG 表现出弱抑制活性，IC50 为 175 µM。MASP-2-IN-1 在小鼠血浆中的稳定性较差，半衰期为 4.4 小时。

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MASP-2-IN-1 Chemical Structure

MASP-2-IN-1 Chemical Structure

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MASP-2-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MASP-2-IN-1 (Compound 77) is the inhibitor for mannan-binding lectin-associated serine protease (MASP), that inhibits MASP2 and MASP3 with IC50 of 11.4 nM and 13.2 µM. MASP-2-IN-1 exhibits a weak inhibitory activity against hERG with an IC50 of 175 µM. MASP-2-IN-1 reveals a poor stability in mouse plasma with a half-life of 4.4 hours[1].

分子量

463.51

Formula

C22H21N7O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MASP-2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MASP-2-IN-1Ser/Thr ProteasePotassium ChannelSerine proteasesSerine endopeptidasesThreonine proteasesKcsAInhibitorinhibitorinhibit

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