Maurocalcine TFA 

Maurocalcine TFA is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine TFA induces [³H]ryanodine binding on RyR1 with an EC₅₀ value of 2558 nM. Maurocalcine TFA exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine TFA can be applied to in vivo cell tracking or other cell imaging techniques^[1][2][3].

Maurocalcine (100 nM, 24 小时) 增加 RyR2 对激活 [Ca²⁺]_i 的敏感性，并降低其对抑制 [Ca_{2+]i 的灵敏度^[1]。
Maurocalcine (5 μM， 4 小时/ 24 小时) 对 HEK293 完全没有细胞毒性^[3]。}

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3858.55 (free base)

C₁₅₆H₂₇₀N₅₆O₄₆S₆.xC₂HF₃O₂

固体

White to off-white

Gly-Asp-Cys-Leu-Pro-His-Leu-Lys-Leu-Cys-Lys-Glu-Asn-Lys-Asp-Cys-Cys-Ser-Lys-Lys-Cys-Lys-Arg-Arg-Gly-Thr-Asn-Ile-Glu-Lys-Arg-Cys-Arg (Disulfide bridge:Cys3-Cys17;Cys10-Cys21;Cys16-Cys32)

GDCLPHLKLCKENKDCCSKKCKRRGTNIEKRCR (Disulfide bridge:Cys3-Cys17;Cys10-Cys21;Cys16-Cys32)

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. De Waard S, et al. Maurocalcin and its analog MCaE12A facilitate Ca2+ mobilization in cardiomyocytes. Biochem J. 2020 Oct 30;477(20):3985-3999.  [Content Brief]

  [2]. Boisseau S, et al. Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. Biochim Biophys Acta. 2006 Mar;1758(3):308-19.

  [3]. Boisseau S, et al. Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. Biochim Biophys Acta. 2006 Mar;1758(3):308-19.  [Content Brief]