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  3. Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice

Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice

  • Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14843-7. doi: 10.1073/pnas.96.26.14843.
K Miyawaki 1,  Y Yamada,  H Yano,  H Niwa,  N Ban,  Y Ihara,  A Kubota,  S Fujimoto,  M Kajikawa,  A Kuroe,  K Tsuda,  H Hashimoto,  T Yamashita,  T Jomori,  F Tashiro,  J Miyazaki,  Y Seino
Affiliations

Affiliation

  • 1 Department of Metabolism, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
PMID: 10611300 DOI: 10.1073/pnas.96.26.14843
Abstract

Mice with a targeted mutation of the gastric inhibitory polypeptide (GIP) receptor gene (GIPR) were generated to determine the role of GIP as a mediator of signals from the gut to pancreatic beta cells. GIPR-/- mice have higher blood glucose levels with impaired initial Insulin response after oral glucose load. Although blood glucose levels after meal ingestion are not increased by high-fat diet in GIPR+/+ mice because of compensatory higher Insulin secretion, they are significantly increased in GIPR-/- mice because of the lack of such enhancement. Accordingly, early Insulin secretion mediated by GIP determines glucose tolerance after oral glucose load in vivo, and because GIP plays an important role in the compensatory enhancement of Insulin secretion produced by a high Insulin demand, a defect in this entero-insular axis may contribute to the pathogenesis of diabetes.

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