2. Academic Validation
  3. Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tü 6040. I. Taxonomy, fermentation, isolation and biological activities

Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tü 6040. I. Taxonomy, fermentation, isolation and biological activities

  • J Antibiot (Tokyo). 2000 Aug;53(8):779-87. doi: 10.7164/antibiotics.53.779.
J Schimana 1,  H P Fiedler,  I Groth,  R Süssmuth,  W Beil,  M Walker,  A Zeeck
Affiliations

Affiliation

  • 1 Mikrobiologisches Institut, Universität Tübingen, Germany.
PMID: 11079799 DOI: 10.7164/antibiotics.53.779
Abstract

Two novel angucyclinone-type Antibiotics, simocyclinones D4 and D8, were detected in the mycelium extract of Streptomyces antibioticus Tü 6040 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compounds show Antibiotic activities against Gram-positive bacteria and cytostatic effects on various tumor cell lines.

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