2. Academic Validation
  3. Inhibition of prolyl endopeptidase by synthetic peptide fragments of human beta-casein

Inhibition of prolyl endopeptidase by synthetic peptide fragments of human beta-casein

  • Agric Biol Chem. 1991 Mar;55(3):825-8.
M Asano 1,  N Nio,  Y Ariyoshi
Affiliations

Affiliation

  • 1 Central Research Laboratories, Ajinomoto Co., Inc., Kawasaki, Japan.
PMID: 1368631
Abstract

It has been suggested that peptide inhibitors of prolyl endopeptidase (PEP) may act as anti-amnestic agents. In the hope of finding PEP inhibitors in milk proteins, we synthesized a total of 37 human beta-casein Peptide Fragments containing proline residues. It was found that the Peptides with PEP inhibition activity in vitro were located in the region of amino acid residues 49-59 of human beta-casein. The most potent inhibitor was Ile-Tyr-Pro-Phe-Val-Glu-Pro-Ile (IC50 = 8 microM).

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z