2. Academic Validation
  3. An anionic inositol phosphate glycan pseudotetrasaccharide exhibits high insulin-mimetic activity in rat adipocytes

An anionic inositol phosphate glycan pseudotetrasaccharide exhibits high insulin-mimetic activity in rat adipocytes

  • Bioorg Med Chem. 2005 Dec 15;13(24):6732-41. doi: 10.1016/j.bmc.2005.07.020.
Nilanjana Chakraborty 1,  Marc d'Alarcao
Affiliations

Affiliation

  • 1 Michael Chemistry Laboratory, Department of Chemistry, Tufts University, Medford, MA 02155, USA.
PMID: 16115771 DOI: 10.1016/j.bmc.2005.07.020
Abstract

Inositol phosphate glycan pseudotetrasaccharides consisting of man-(alpha1-6)-man-(alpha1-4)-glcN-(alpha,beta1-6)-myo-inositol-1,2-cyclic phosphate possessing a sulfate group at either O-6 (compounds 3alpha,beta) or O-2 (compounds 4alpha,beta) of the terminal mannose have been prepared. Compound 4alpha was able to stimulate lipogenesis in native rat adipocytes to 78% of the maximal Insulin response (MIR) with an EC50 of 1.1 microM. The Other compounds exhibited lower maximal stimulations (47-63% MIR) and higher EC50 values (9.5-10.6 microM).

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