2. Academic Validation
  3. New sesquicillins, insecticidal antibiotics produced by Albophoma sp. FKI-1778

New sesquicillins, insecticidal antibiotics produced by Albophoma sp. FKI-1778

  • J Antibiot (Tokyo). 2005 Jun;58(6):397-404. doi: 10.1038/ja.2005.50.
Ryuji Uchida 1,  Rie Imasato,  Yuichi Yamaguchi,  Rokuro Masuma,  Kazuro Shiomi,  Hiroshi Tomoda,  Satoshi Omura
Affiliations

Affiliation

  • 1 The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 1088641, Japan.
PMID: 16156516 DOI: 10.1038/ja.2005.50
Abstract

Four new Antibiotics, sesquicillins B to E were isolated from the culture broth of Albophoma sp. FKI-1778 together with known sesquicillin (sesquicillin A in this paper). The structures of sesquicillins were elucidated by spectroscopic studies including various NMR experiments. All sesquicillins have a common pyrano-diterpene skeleton. Sesquicillins showed moderate inhibitory activity against the growth of Artemia salina (brine shrimps) and Jurkat cells.

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