2. Academic Validation
  3. The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs

The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs

  • Bioorg Med Chem Lett. 2006 Jan 1;16(1):142-5. doi: 10.1016/j.bmcl.2005.09.024.
Young-Ger Suh 1,  Sun Nam Kim,  Dong-Yun Shin,  Soon-Sil Hyun,  Do-Sang Lee,  Kyung-Hoon Min,  Sae Mi Han,  Funan Li,  Eung-Chil Choi,  Seong-Hak Choi
Affiliations

Affiliation

  • 1 College of Pharmacy, Seoul National University, San 56-1 Shinrim-Dong, Kwanak-Gu, Seoul 151-742, Republic of Korea. ygsuh@snu.ac.kr
PMID: 16236511 DOI: 10.1016/j.bmcl.2005.09.024
Abstract

For the systematic SAR study on mansonone F, a series of C6 and C9 analogs of mansonone F have been synthesized and their anti-MRSA activities were evaluated. Most of the analogs exhibited good or excellent anti-MRSA activities. In particular, the 6-n-butylmansonone F showed fourfold higher Antibacterial activities compared to that of vancomycin.

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