2. Academic Validation
  3. Indoloprodigiosins from the C-10 bipyrrolic precursor: new antiproliferative prodigiosin analogs

Indoloprodigiosins from the C-10 bipyrrolic precursor: new antiproliferative prodigiosin analogs

  • Bioorg Med Chem Lett. 2006 Feb;16(3):701-4. doi: 10.1016/j.bmcl.2005.10.027.
Carmen M Baldino 1,  Jonathan Parr,  Christopher J Wilson,  Shi-Chung Ng,  Daniel Yohannes,  Harry H Wasserman
Affiliations

Affiliation

  • 1 ArQule Inc. 19 Presidential Way, Woburn, MA 01801-5140, USA. carmen.baldino@bioduro.com
PMID: 16289814 DOI: 10.1016/j.bmcl.2005.10.027
Abstract

The condensation of the C-10 methoxybipyrrole precursor (3) of prodigiosin with indoles and a related pyrrole derivative yields novel analogs of prodigiosin. Biological evaluation of these products revealed compounds that inhibit Cancer cell proliferation from 50 nM to 50 microM.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z