2. Academic Validation
  3. Three new lignans, longipedunins A-C, from Kadsura longipedunculata and their inhibitory activity against HIV-1 protease

Three new lignans, longipedunins A-C, from Kadsura longipedunculata and their inhibitory activity against HIV-1 protease

  • Chem Pharm Bull (Tokyo). 2006 Jan;54(1):129-32. doi: 10.1248/cpb.54.129.
Quan-Zhong Sun 1,  Dao-Feng Chen,  Pei-Lan Ding,  Chao-Mei Ma,  Hiroko Kakuda,  Norio Nakamura,  Masao Hattori
Affiliations

Affiliation

  • 1 Department of Pharmacognosy, School of Pharmacy, Fudan University.
PMID: 16394567 DOI: 10.1248/cpb.54.129
Abstract

Three new Lignans, longipedunins A (1), B (2) and C (3), together with three known compounds, benzoyl-binankadsurin A (4), acetyl-binankadsurin A (5) and schisanlactone A (6), were isolated from Kadsura longipedunculata. Their structures and stereochemistry were determined by spectral and single-crystal X-ray analyses. Compounds 1 and 6 showed appreciable inhibitory activity against HIV-1 protease with IC50 values of 50 and 20 microM, respectively.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z