2. Academic Validation
  3. Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus

Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus

  • Planta Med. 2005 Dec;71(12):1128-33. doi: 10.1055/s-2005-873169.
Haibo Li 1,  Changxin Zhou,  Yunxue Pan,  Xiaozhong Gao,  Xiumei Wu,  Hua Bai,  Linfu Zhou,  Zhi Chen,  Shuili Zhang,  Shuyun Shi,  Jiali Luo,  Juanhua Xu,  Liurong Chen,  Xiaoxiang Zheng,  Yu Zhao
Affiliations

Affiliation

  • 1 Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China.
PMID: 16395649 DOI: 10.1055/s-2005-873169
Abstract

Nineteen compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus were tested for inhibitory effects on hepatitis B virus (HBV) and Herpes simplex virus type-1 (HSV-1). The results showed that apigenin 4'- O- alpha-rhamnopyranoside, apigenin 7- O- beta-glucopyranosyl-4'- O- alpha-rhamnopyranoside, tricin 7- O- beta-glucopyranoside, tricin, and isoscopoletin possessed inhibitory activity against HBV replication. Protocatechuyl aldehyde exhibited an inhibiting activity on HSV-1 replication. It is therefore suggested that further investigations on these bioactive compounds might be needed to discover and develop new Antiviral agents.

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