2. Academic Validation
  3. Three-membered ring sesquiterpenoids with NGF-potentiating activity from the roots of Valeriana fauriei

Three-membered ring sesquiterpenoids with NGF-potentiating activity from the roots of Valeriana fauriei

  • Planta Med. 2006 Mar;72(4):373-5. doi: 10.1055/s-2005-916210.
Yuanqiang Guo 1,  Jing Xu,  Yushan Li,  Tohru Yamakuni,  Yasushi Ohizumi
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
PMID: 16557481 DOI: 10.1055/s-2005-916210
Abstract

Three novel three-membered ring sesquiterpenoids, named kissoone A (1), kissoone B (2), and its acetylated product, kissoone C (3), were isolated from the roots of Valeriana fauriei. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2 and 3 showed enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PC 12D cells.

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