2. Academic Validation
  3. Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family

Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family

  • FEBS Lett. 2006 Jul 24;580(17):4057-64. doi: 10.1016/j.febslet.2006.06.043.
Taisuke Miyazaki 1,  Kouichi Hashimoto,  Atsushi Uda,  Hiroyuki Sakagami,  Yoshitaka Nakamura,  Shin-ya Saito,  Miyuki Nishi,  Hideaki Kume,  Akira Tohgo,  Izumi Kaneko,  Hisatake Kondo,  Kohji Fukunaga,  Masanobu Kano,  Masahiko Watanabe,  Hiroshi Takeshima
Affiliations

Affiliation

  • 1 Department of Anatomy, Hokkaido University, School of Medicine, Sapporo, Japan.
PMID: 16814779 DOI: 10.1016/j.febslet.2006.06.043
Abstract

By DNA cloning, we have identified the BSRP (brain-specific receptor-like proteins) family of three members in mammalian genomes. BSRPs were predominantly expressed in the soma and dendrites of neurons and localized in the endoplasmic reticulum (ER). Expression levels of BSRPs seemed to fluctuate greatly during postnatal cerebellar maturation. Triple-knockout mice lacking BSRP members exhibited motor discoordination, and Purkinje cells (PCs) were often innervated by multiple climbing fibers with different neuronal origins in the mutant cerebellum. Moreover, the phosphorylation levels of protein kinase Calpha (PKCalpha) were significantly downregulated in the mutant cerebellum. Because cerebellar maturation and plasticity require metabotropic glutamate receptor signaling and resulting PKC activation, BSRPs are likely involved in ER functions supporting PKCalpha activation in PCs.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z